Amodio studied music, architecture, and painting in his native country of Uruguay before emigrating to the US in 1964. He started painting exclusively in 1966 in New York. On Nantucket he teamed up with Dean Taylor and Pat Gardner to form a visual arts gallery, PAD, at Pat's property on Hummock Pond Road. From 1969-71 he partnered with Dean Taylor in the Amodio-Taylor Gallery at 45 Orange Street.
He exhibited at the Main Street Gallery in its early years, and he had an exhibition of 30 pastel drawings in 8.5 inch circular format at the Little Gallery in 1971.
In the I&M in August 1971 he said, "I started working with the circle last summer. I have seen some Japanese paintings done inside a circle. A composition inside a circle is more difficult to balance, to make look like a painting and not like a plate...that's the danger. You can become decorative."
He studied on scholarship at Haystack Mountain School of Crafts, on Deer Island, ME.